Nonspecific craniovertebral spondylitis: features of surgical tactics
https://doi.org/10.14531/ss2024.4.80-90
Abstract
Objective. To evaluate the effectiveness of surgical treatment of nonspecific spondylitis in the area of craniovertebral junction taking into account the clinical and pathomorphological features of the disease.
Material and Methods. The study included 11 patients with nonspecific craniovertebral spondylitis: 4 women and 7 men aged 31 to 75 years. In 8 patients, the clinical picture was represented by neurological symptoms, and in 3 – by pain syndrome. Combined interventions were performed in 7 patients who had compression of the spinal cord and medulla oblongata. Of these, 5 patients first underwent transoral decompression, and then occipitospondylodesis. In the rest patients, the sequence of surgical treatment had the reverse order. In 6 cases, combined operations were performed simultaneously, and in one case — with an interval of 7 days. In one patient, the first stage was external ventricular drainage of hydrocephalus due to occlusion of the cerebrospinal fluid pathways by a displaced odontoid process, and the second stage was transoral decompression. Patients with pain syndrome underwent occipitospondylodesis. In one case, after combined surgery, ventriculoperitoneal shunting was performed for aresorptive hydrocephalus that developed after meningitis.
Results. In 10 patients, the pain intensity according to VAS decreased by 5–7 points (6.3 on average) in the postoperative period. Out of 8 patients with conductor symptoms, regression of neurological disorders after surgery was achieved in 3, complete recovery (Frankel E) in 4, and one patient died of purulent ventriculitis. Control examination of 10 patients confirmed the relief of the inflammatory process and the absence of compression of the spinal cord and medulla oblongata. Among the early postoperative complications, one case of postoperative liquorrhea and the divergence of the edges of the wound of the posterior pharyngeal wall were recorded. Fracture of metal structure elements was observed in one patient 3 years after surgery.
Conclusion. In nonspecific craniovertebral spondylitis, an active surgical tactic is justified. Occipitospondylodesis at an early stage of the disease allows to eliminate atlantoaxial instability and prevent the associated risk of neurological complications. In conduction disorders, if the patient’s condition allows, simultaneous transoral decompression and craniocervical fixation is the best option for surgical treatment of nonspecific spondylitis of the craniovertebral region. Preservation of mobility in the cervical spine facilitates the transoral stage, therefore occipitospondylodesis is advisable to be performed at the second stage.
About the Authors
I. Yu. LisitskyRussian Federation
MD, PhD, Associate Professor of the Department of traumatology, orthopedics and disaster surgery
V. A. Khomenko
Russian Federation
DMSc, Prof., leading researcher of the Surgery Department
A. V. Lychagin
Russian Federation
DMSc, Prof., Head of the Department of traumatology, orthopedics and disaster surgery
A. Yu. Zarov
Russian Federation
Assistant Professor of the Department of traumatology, orthopedics and disaster surgery
A. L. Korkunov
Russian Federation
MD, PhD, Associate Professor of the Department of traumatology, orthopedics and disaster surgery
V. G. Cherepanov
Russian Federation
DMSc, Professor of the Department of traumatology, orthopedics and disaster surgery
I. A. Vyazankin
Russian Federation
Assistant Professor of the Department of traumatology, orthopedics and disaster surgery
E. Yu. Tselishcheva
Russian Federation
MD, PhD, Associate Professor of the Department of traumatology, orthopedics and disaster surgery
References
1. Makins GH, Abbott FC. II. On acute primary osteomyelitis of the vertebrae. Ann Surg. 1896;23:510–539. DOI: 10.1097/00000658-189601000-00099.
2. Malawski SK, Lukawski S. Pyogenic infection of the spine. Clin Orthop Relat Res. 1991;(272):58–66. DOI: 10.1097/00003086-199111000-00009.
3. Kobayashi T, Ureshino H, Morimoto T, Shimanoe C, Ikuta K, Sonohata M, Mawatari M. Treatment strategy for upper cervical epidural abscess: a literature review. Nagoya J Med Sci. 2021;83:1–20. DOI: 10.18999/nagjms.83.1.1.
4. Zigler JE, Bohlman HH, Robinson RA, Riley LH, Dodge LD. Pyogenic osteomyelitis of the occiput, the atlas, and the axis. A report of five cases. J Bone Joint Surg Am. 1987;69:1069–1073. DOI: 10.2106/00004623-198769070-00016.
5. Киселев А.М., Лавров В.Н. Воспалительные процессы краниовертебральной области: клиника, диагностика, тактика хирургического лечения // Нейрохирургия. 2015. № 1. С. 29–36. [Kiselev AM, Lavrov VN. The inflammatory processes in craniovertebral region: clinical signs, diagnostics and surgical treatment strategy. Russian Journal of Neurosurgery. 2015;(1):29–36].
6. Лисицкий И.Ю., Лычагин А.В., Заров А.Ю., Коркунов А.Л., Черепанов В.Г., Вязанкин И.А., Целищева Е.Ю. Неспецифические спондилиты краниовертебральной области // Журнал «Вопросы нейрохирургии» им. Н.Н. Бурденко. 2024. Т. 88. № 3. С. 21–30. [Lisitsky IYu, Lychagin AV, Zarov AYu, Korkunov AL, Cherepanov VG, Vyzankin IA, Tselishcheva EYu. Nonspecific craniovertebral spondylitis. Burdenko Journal of Neurosurgery. 2024;88(3):21–30].
7. DOI: 10.17116/neiro20248803121.
8. Parke WW, Rothman RH, Brown MD. The pharyngovertebral veins: an anatomical rationale for Grisel’s syndrome. J Bone Joint Surg Am. 1984;66:568–574. DOI: 10.2106/00004623-198466040-00012.
9. Al-Hourani K, Al-Aref R, Mesfin A. Upper cervical epidural abscess in clinical practice: diagnosis and management. Global Spine J. 2016;6:383–393. DOI: 10.1055/s-0035-1565260.
10. Venger BH, Musher DM, Brown EW, Baskin DS. Isolated C-2 osteomyelitis of hematogenous origin: case report and literature review. Neurosurgery. 1986;18:461–464. DOI: 10.1227/00006123-198604000-00013.
11. Goulart CR, Mattei TA, Fiore ME, Thoman WJ, Mendel E. Retropharyngeal abscess with secondary osteomyelitis and epidural abscess: proposed pathophysiological mechanism of an underrecognized complication of unstable craniocervical injuries: case report. J Neurosurg Spine. 2016;24:197–205. DOI: 10.3171/2015.4.SPINE14952.
12. Yamane К, Nagashima H, Tanishima S, Teshima R. Severe rotational deformity, quadriparesis and respiratory embarrassment due to osteomyelitis at the occipito-atlantoaxial junction. J Bone Joint Surg Br. 2010;92:286–288. DOI: 10.1302/0301-620X.92B2. 22984.
13. Ruskin J, Shapiro S, McCombs M, Greenberg H, Helmer E. Odontoid osteomyelitis. An unusual presentation of an uncommon disease. West J Med. 1992;156:306–308.
14. Kubo S, Takimoto H, Hosoi K, Toyota S, Karasawa J, Yoshimine T. Osteomyelitis of the odontoid process associated with meningitis and retropharyngeal abscess – case report. Neurol Med Chir (Tokyo) 2002;42:447–451. DOI: 10.2176/nmc.42.447.
15. Keogh S, Crockard A. Staphylococcal infection of the odontoid peg. Postgrad Med J. 1992;68(795):51–54. DOI: 10.1136/pgmj.68.795.51.
16. Kim JY, Ji GY, Yi S, Ha Y, Kim KN, Yoon DH. Spontaneous atlantoaxial subluxation due to pyogenic or tuberculosis vertebral osteomyelitis: diagnosis and treatment. Kor J Spine. 2010;7:131–136.
17. Ueda Y, Kawahara N, Murakami H, Matsui T, Tomita K. Pyogenic osteomyelitis of the atlas: а case report. Spine. 2009;34:E342–E345.
18. DOI: 10.1097/BRS.0b013e318198c805.
19. Sasaki K, Nabeshima Y, Ozaki A, Mori H, Fujii H, Sumi M, Doita M. Septic arthritis of the atlantoaxial joint: case report. J Spinal Disord Tech. 2006;19:612–615. DOI: 10.1097/01.bsd.0000211234.68469.92.
20. Kobayashi T, Ureshino H, Hotta K, Ikuta K. Timing of surgical interventions for upper cervical epidural abscess: a case report and review of the literature. Eur J Orthop Surg Traumatol. 2019;29:1365–1366. DOI: 10.1007/s00590-019-02425-3.
21. Tsunoda K, Iizuka H, Sorimachi Y, Ara T, Nishinome M, Takechi Y, Takagishi K. Atlanto-axial subluxation after pyogenic spondylitis of the atlanto-occipital joint. Eur Spine J. 2011;20(Suppl 2):253–257. DOI: 10.1007/s00586-010-1651-z.
22. Suchomel P, Buchvald P, Barsa P, Lukas R, Soukup T. Pyogenic osteomyelitis of the odontoid process: single stage decompression and fusion. Spine. 2003;28:E239–E244. DOI: 10.1097/01.BRS.0000065489.02720.D8.
23. Wiedau-Pazos M, Curio G, Grusser C. Epidural abscess of the cervical spine with osteomyelitis of the odontoid process. Spine. 1999;24:133–136. DOI: 10.1097/00007632-199901150-00008.
24. Aranibar RJ, Del Monaco DC, Gonzales P. Anterior microscopic transtubular (MITR) surgical approach for cervical pyogenic C1–2 abscess: a case report. Int J Spine Surg. 2015;9:56. DOI: 10.14444/2056.
25. Dlouhy BJ, Dahdaleh NS, Menezes AH. Evolution of transoral approaches, endoscopic endonasal approaches, and reduction strategies for treatment of craniovertebral junction pathology: a treatment algorithm update. Neurosurg Focus. 2015;38:E8. DOI: 10.3171/2015.1.FOCUS14837.
26. Fang HS, Ong GB. Direct anterior approach to the upper cervical spine. J Bone Joint Surg. 1962;44:1588–1604.
27. Burns TC, Mindea SA, Pendharkar AV, Lapustea NB, Irime I, Nayak JV. Endoscopic transnasal approach for urgent decompression of the craniocervical junction in acute skull base osteomyelitis. J Neurol Surg Rep. 2015;76:e37–e42. DOI: 10.1055/s-0034-1395492.
28. Keister A, Vignolles-Jeong J, Kreatsoulas D, VanKoevering K, Viljoen S, Prevedello D, Grossbach AJ. Endoscopic endonasal resection of craniovertebral junction osteomyelitis: illustrative cases. J Neurosurg Case Lessons. 2023;5:CASE22290. DOI: 10.371/CASE22290.
Review
For citations:
Lisitsky I.Yu., Khomenko V.A., Lychagin A.V., Zarov A.Yu., Korkunov A.L., Cherepanov V.G., Vyazankin I.A., Tselishcheva E.Yu. Nonspecific craniovertebral spondylitis: features of surgical tactics. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2024;21(4):80-90. https://doi.org/10.14531/ss2024.4.80-90