КЛЕТОЧНЫЕ МАТРИЦЫ (СКАФФОЛДЫ) ДЛЯ ЦЕЛЕЙ РЕГЕНЕРАЦИИ КОСТИ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ


https://doi.org/10.14531/ss2014.2.79-86

Полный текст:


Аннотация

В обзоре рассмотрены необходимые свойства тканеинженерных скаффолдов для обеспечения остеогенной дифференцировки, межклеточных сигнальных взаимодействий и васкуляризации скаффолда, которые во многом обеспечиваются за счет архитектуры скаффолда: наличия пористости и размеров пор, наличия и влияния канальной взаимосвязанности пор скаффолда на межклеточные взаимодействия. На основе литературных сведений показано, что геометрия поверхности, размеры пор и канальцев, обеспечивающих внутренние коммуникации между порами в матрице, собственно микроархитектура матрицы, рассматриваемые даже без учета влияния ростовых факторов и материалов, из которых изготовлены матрицы, могут оказывать влияние на клеточную пролиферацию, остеогенную индукцию и остеокондуктивные свойства, что реализуется через межклеточные взаимодействия.

Об авторах

Михаил Анатольевич Садовой
Новосибирский НИИ травматологии и ортопедии им. Я.Л. Цивьяна
Россия


Петр Михайлович Ларионов
Новосибирский НИИ травматологии и ортопедии им. Я.Л. Цивьяна
Россия


Александр Геннадьевич Самохин
Новосибирский НИИ травматологии и ортопедии им. Я.Л. Цивьяна
Россия


Ольга Михайловна Рожнова
Новосибирский НИИ травматологии и ортопедии им. Я.Л. Цивьяна
Россия


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Дополнительные файлы

Для цитирования: Садовой М.А., Ларионов П.М., Самохин А.Г., Рожнова О.М. КЛЕТОЧНЫЕ МАТРИЦЫ (СКАФФОЛДЫ) ДЛЯ ЦЕЛЕЙ РЕГЕНЕРАЦИИ КОСТИ: СОВРЕМЕННОЕ СОСТОЯНИЕ ПРОБЛЕМЫ. "Хирургия позвоночника". 2014;(2):79-86. https://doi.org/10.14531/ss2014.2.79-86

For citation: Sadovoy M.A., Larionov P.M., Samokhin A.G., Rozhnova O.M. CELLULAR MATRICES (SCAFFOLDS) FOR BONE REGENERATION: STATE OF THE ART. Hirurgiâ pozvonočnika (Spine Surgery). 2014;(2):79-86. (In Russ.) https://doi.org/10.14531/ss2014.2.79-86

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