СРАВНИТЕЛЬНЫЙ АНАЛИЗ ОСТЕОИНТЕГРАЦИИ АЛЮМООКСИДНЫХ БИОКЕРАМИЧЕСКИХ ГРАНУЛ В ЭКСПЕРИМЕНТЕ

Цель исследования. Сравнительный анализ остеоинтеграции биокерамических гранул на основе оксида алюминия, гидроксиапатита и гранул депротеинизированной костной ткани.
Материал и методы. Эксперимент проведен на 52 половозрелых самцах лабораторных крыс Kyoto-Wistar массой от 350 до 520 г. Из животных сформировано пять однородных групп, которые различались только видом
имплантированного материала. Гранулы имплантированы в тела поясничных позвонков и в дистальный отдел правой бедренной кости каждого лабораторного животного. Через два месяца после операций проводили эвтаназию лабораторных животных с последующим забором тканей для проведения морфологических исследований.
Результаты. При исследовании препаратов из групп с имплантацией алюмооксидных гранул обнаруживалась сформированная костная ткань трабекулярного строения со следами перестройки. Костная ткань заполняла
пространство между гранулами и плотно прилегала к их поверхности. На границе между костной тканью и гранулами алюмооксидной биокерамики соединительно-тканная капсула отсутствовала.
Заключение. Биокерамические гранулы на основе оксида алюминия в виде цилиндров со сквозным внутренним каналом обладают высокой прочностью, превосходящей аналоги, и способностью к остеоинтеграции, близкой к биокерамическим гранулам на основе гидрокисапатита и депротеинизированной костной ткани.

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