HISTOLOGICAL AND HISTOMORPHOMETRIC STUDY OF THE POROUS NITI OSSEOINTEGRATION USED LIKE INTERVERTEBRAL FUSION IMPLANT
Abstract
An implant for intervertebral fusion made of porous nickeltitanium (PNT) was evaluated in the ewe. Sixteen ewes received each one two implants: the system «Bagby and Kuslich» (BAK) being used as control and the PNT. The objective was to evaluate the osteointegration, osteoconduction and bone growth in the presence of these two cages subjected to the same mechanical loads. After implantation, the sheeps were sacrificed by group to three different periods: three, six and twelve months, and the spines carrying the implant were taken. The qualitative (microscopic and visual observation) and quantitative (histomorphometry) histological analyses were carried out on histological slices of cages and adjacent tissues. The results indicated that the PNT, had performed better than the BAK. A rigorous statistical analysis of these results made it possible to confirm this observation. The performance of two implants seemed to be influenced by the biofonctionnality which is related to the structure and the shape of the implant. The biocompatibility of two implants seemed however comparable.
About the Authors
Fidele Likibi
Hospital Sainte-Justine, Centre de Recherche Pediatrique, Ecole Polytechnique/Universite de Montreal, Institut de Genie Biomedical
Russian Federation
Russian Federation
Sylvie Charette
Research Center, Sainte-Justine Hospital, Montreal, Canada
Russian Federation
Russian Federation
Michel Assad
Biorthex Inc., Montreal, Canada
Russian Federation
Russian Federation
Christine Coillard
Research Center, Sainte-Justine Hospital, Montreal, Canada
Russian Federation
Russian Federation
Gilles Chabot
Hospital Sainte-Justine, Centre de Recherche Pediatrique
Russian Federation
Russian Federation
Charles-Hilaire Rivard
Research Center, Sainte-Justine Hospital, Montreal, Canada; Ecole Polytechnique/Universite de Montreal, Institut de Genie Biomedical; 3Biorthex Inc., Montreal (QC), Canada
Russian Federation
Russian Federation
References
1. Shabalovskaya SA. On the nature of the biocompatibility and on medical applications of NiTi shape memory and superelastic alloys. Biomed Mater Eng 6: 267-289; 1996.
2. Gunter VE. Superelastic shape memory implants in maxillofacial surgery. Traumatology, Orthopaedics and Neurosurgery. Tomsk, Russia; 1995.
3. Perrkins J, Hodgson D. The two-way shape memory alloys, dans Shape memory in engineering aspects of shape memory alloys. Melton KN, Stöckel D, Wayman CM, Duenrig TW, Butterworth-heinemann, London, UK: 195-206; 1990.
4. Brailovski V, Trochu F. Review of shape memory alloys medical applications in Russia. Biomed Mater Eng 6: 291-298; 1996.
5. Kuo PPF, Yang PJ, Zhang YF, Yang HB, Yu YF, Dai KR, Hong WQ, Ke MZ, Cai TD, Tao JC. The use of nickel-titanium alloy in orthopaedic surgery in China. Orthopaedics 12: 111-116; 1989.
6. Hernández R, Polizu S, Turenne S, Yahia l’H. Characteristics of porous nickel-titanium alloys for medical applications. Biomed Mater Eng 12: 37-45; 2002.
7. Gotthardt R, Lehnert T. Alliages à mémoire de forme, dans Matériaux émergents. Vol. 19. Janot C, Iischner B. Presses polytechniques universitaires romandes, Suisse; 2001.
8. Smit TH. The use of quadruped as an in vivo model for the study of the spine - biomechanical considerations. Eur Spine J 11: 137-144; 2002.
9. Karpinski MR, Szymanska M. Posterior lumbar interbody fusion and cages. Chir Narzadow Ruchu Ortop Pol 64: 463-470; 1999.
10. Sandhu HS, Turner S, Kabo MJ, Kanim LEA, Liu D, Nourparvar A, Delamarter RB, Dawson EG. Distractive properties of a threaded interbody fusion device. Spine 21: 1201-1210; 1996.
11. Lu S. Medical applications of NiTi alloys in China, dans Shape Memory in Engineering Aspects of Shape Memory Alloys. Melton KN, Stöckel D, Wayman CM, Duenrig TW, Butterworth-Heinemann, London, UK: 445-446; 1990.
12. Steffen T, Tsantrizos A, Fruth I, Aebi M. Cages: designs and concepts. Eur Spine J 9: S89-S94; 2000.
13. Kim TI, Han JH, Lee IS, Lee KH, Shin MC, Choi BB. New titanium alloys for biomaterials: a study of mechanical and corrosion properties and cytotoxicity. Biomed Mater Eng 7: 253-263; 1997.
14. Khan MA, Williams RL, Williams DF. Conjoint corrosion and wear in titanium alloys. Biomaterials 20: 765-772; 1999.
15. Yoda S, Sakurai Y, Endo A, Miyata T, Otake K, Yanagishita H, Tsuchiya T. TiO2 montmorillonite composites via supercritical intercalation. Chem Commun 14: 1526-1527; 2002.
16. Hodges CD, Humphreys SC, Eck JC, Murphy RB. Intraoperative loosening of Bagby and Kuslich Cages during anterior lumbar interbody fusion. J Spinal Disorders 13: 535-537; 2000.
17. Meraw SJ, Reeve CM, Wollan PC. Use of alendronate in peri-implant defect regeneration. J Periodontol 70: 151-158; 1999.
18. Froum S, Cho SC, Rosenberg E, Rohrer M, Tarnow D. Histological comparison of healing extraction sockets implanted with bioactive glass or demineralized freeze-dried bone allograft: a pilot study. J Periodontol 73: 94-102; 2002.
19. Assad M, Jarzem P, Leroux MA, Coillard C, Charette S, Rivard CH. Porous nitinol for lumbar intervertebral fusion in a sheep model: part 1. Histomorphometric and radiological analysis. J Biomed Mater Res 64B: 107-120; 2003.
20. Carvalho LC, König JB. Histological findings of bone remodelling around smooth dental titanium implants inserted in rabbit’s tibias. Ann Anat 184: 359-362; 2002.
21. Schroeder A, van der Zypen E, Stich H, Sutter F. The reactions of bone, connective tissue, and epithelium to endosteal implants with titanium-sprayed surfaces. J Maxillofac Surg 9: 15-25; 1981.
22. Kuslich SD, Ulstrom CL, Griffith SL, Ahern JW, Dowdle JD. The Bagby and Kuslich method of lumbar interbody fusion. History, techniques, and 2-years follow-up results of a United States prospective, multicenter trial. Spine 23: 1267-79; 1998.
23. Bagby G. The Bagby and Kuslich (BAK) method of lumbar interbody fusion. Spine 24: 1857; 1999.
24. Gautier E, Perren SM, Cordey J. Strain distribution in the plated and unplated sheep tibia: an in vivo experiment. Injury 31: C37-44; 2000.
25. Glassman AH, Crowninshield RD, Schenck R, Herberts P. A low stiffness composite biologically fixed prosthesis. Clin Orthop 393: 128-36; 2001.
Review
For citations:
Likibi F., Charette S., Assad M., Coillard Ch., Chabot G., Rivard Ch. HISTOLOGICAL AND HISTOMORPHOMETRIC STUDY OF THE POROUS NITI OSSEOINTEGRATION USED LIKE INTERVERTEBRAL FUSION IMPLANT. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2004;(1):121-127. (In Russ.)
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