STRUCTURAL AND FUNCTIONAL CHANGES IN BONE TISSUE OF THE SPINE AND EXTREMITIES IN OXYS RATS
https://doi.org/10.14531/ss2006.1.88-94
Abstract
Objective. To study specific structural and functional changes in bone tissue in Oxys rats of different age.
Material and Methods. Mineral density of bone tissue in Oxys and Wistar male rats at the age of 2–18 months was examined with x-ray bone densitometer LUNAR-Exert-XL (USA). Bone fragments of vertebral bodies and of forelegs and hind legs were studied by histomorphometric assay with software Motic Images Plus 2.0 ML (Micromed, Russia).
Results. X-ray bone densitometry findings have shown that bone mineral density increase in Oxys rats does not attain the values shown by age-matched control rats, and progressively decreases after the age of 6 months. Data obtained by histomorphometric analysis of vertebral bodies and limbs have reliably demonstrated that there is a change in quantitative and qualitative bone tissue parameters of Oxys rats which is a characteristic of osteoporosis.
Conclusion. Bone tissue changes in Oxys rats correspond to that observed in human osteoporosis, what allows to use rat as a model for the study of osteoporosis pathogenesis and for development of prophylaxis and treatment methods.
About the Authors
Olga Viktorovna Falameeva
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Mikhail Anatolyevich Sadovoy
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Yulia Viktorovna Khrapova
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Natalya Gorislavovna Kolosova
Institute of Citology and Genetics, SB RAS, Novosibirsk
Russian Federation
Russian Federation
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Review
For citations:
Falameeva O.V., Sadovoy M.A., Khrapova Yu.V., Kolosova N.G. STRUCTURAL AND FUNCTIONAL CHANGES IN BONE TISSUE OF THE SPINE AND EXTREMITIES IN OXYS RATS. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2006;(1):088-094. (In Russ.) https://doi.org/10.14531/ss2006.1.88-94
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