POTENTIAL BIOCHEMICAL MARKERSOF IDIOPATHIC SCOLIOSIS PROGRESSION
https://doi.org/10.14531/ss2011.1.62-67
Abstract
Objective. To clarify specific signs of idiopathic scoliosis progression that may be associated with change in glycosaminoglycan turnover.
Material and Methods. Blood serum samples from 180 adolescents aged 11–14 years with grade I–IV idiopathic scoliosis were tested for sulphated glycosaminoglycan levels, and for activity of lysosomal glycosidases (hyaluronidase, N-acetyl- β-D-glucosaminidase, β-glucuronidase, and α-galactosidase) and cathepsine D.
Results. Reduction in serum sulfated glycosaminoglycan levels, as compared to the levels of healthy subjects, was revealed in 25 % of adolescents with early stages of spinal deformity development, and in more than 70 % of those with idiopathic scoliosis of grade III–IV. Activity of α-galactosidase in adolescents with high grade of deformity 3–10 times exceeded that of in normal subjects. Any correlation between a change in the activity of other blood lysosomal glycosidases and a degree of scoliosis was not revealed.
Conclusion. The obtained data demonstrate that levels of examined sulphated glycosaminoglycans and α-galactosidase activity are in certain correlation with a grade of scoliotic deformity of the spine. Thus, these characteristics may be considered as a kind of biochemical markers of idiopathic scoliosis progression, and further study of glycosaminoglycan and galactose metabolism may be one of the prospective directions in studies of idiopathic scoliosis pathogenesis.
About the Authors
Tatyana Vasilyevna Rusova
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Natalya Valeryevna Shaidurova
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Alla Mikhailovna Zaidman
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
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Review
For citations:
Rusova T.V., Shaidurova N.V., Zaidman A.M. POTENTIAL BIOCHEMICAL MARKERSOF IDIOPATHIC SCOLIOSIS PROGRESSION. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2011;(1):062-067. (In Russ.) https://doi.org/10.14531/ss2011.1.62-67
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