APPLICATION OF THE APPARENT DIFFUSION COEFFICIENT IN PREOPERATIVE ASSESSMENT OF THE PROLIFERATIVE POTENTIAL OF SPINAL TUMORS
https://doi.org/10.14531/ss2017.3.93-99
Abstract
Objective. To analyze and compare the measured values of apparent diffusion coefficient (ADC) in tumors of the spinal canal with cell density and Ki-67 index of proliferative activity.
Material and Methods. The study included diffusion-weighted MR images of 36 patients with different types of tumors of the spinal canal. In the morphological study of tumors, the degree of malignancy according to the WHO classification, the value of the Ki-67 index, and cell density were assessed.
Results. The average ADC of the extradural tumors G = I–II and G = III–IV was 1390.0 ± 94.8 mm2/s and 821.3 ± 111.1 mm2/sec, respectively. For intradural extramedullary neoplasms G = I–II, the ADC was 1328.7 ± 172.1 mm2/sec, for G = III – 957.6 ± 50.7 mm2/sec. Intramedullary tumors G = I–II had an average ADC value of 1604.6 ± 28.7 mm2/sec, and tumors G = III – 1066.5 ± 74.2 mm2/sec. For extradural tumors G = I–II, the Ki-67 index varied from 2 to 4 %, and for tumors G = III–IV – from 12 to 27 %; in the group of intradural extramedullary tumors G = I–II – from 1 to 5 %, for tumors G = III – from 7 to 11 %; for intramedullary tumors G = I–II – from 2 to 6 %, and for G = III tumors – from 7 to 19 %.
Conclusion. The diffusion-weighted MRI with ADC counting can be used as an additional non-invasive method for preoperative evaluation of the proliferative potential of a number of spinal canal tumors.
About the Authors
Vadim A. Byvaltsev
Irkutsk State Medical University;
Road Clinical Hospital at «Irkutsk-Passazhirskiy» station;
Irkutsk Scientific Centre of Surgery and Traumatology;
Irkutsk State Medical Academy of Continuing Education
Russian Federation
DMSc, Chief neurosurgeon of the Health Department of JSCo «Russian Railways», head of the Centre of Neurosurgery, Road Clinical Hospital at «Irkutsk-Passazhirskiy» station of JSCo «Russian Railways», director of the course of neurosurgery, Irkutsk State Medical University, head of scientificclinical department of neurosurgery of the Irkutsk Scientific Centre of Surgery and Traumatology, Professor of the Department of Traumatology, Orthopaedics and Neurosurgery of Irkutsk State Medical Academy of Continuing Education, Irkutsk, Russia
Russian Federation
DMSc, Chief neurosurgeon of the Health Department of JSCo «Russian Railways», head of the Centre of Neurosurgery, Road Clinical Hospital at «Irkutsk-Passazhirskiy» station of JSCo «Russian Railways», director of the course of neurosurgery, Irkutsk State Medical University, head of scientificclinical department of neurosurgery of the Irkutsk Scientific Centre of Surgery and Traumatology, Professor of the Department of Traumatology, Orthopaedics and Neurosurgery of Irkutsk State Medical Academy of Continuing Education, Irkutsk, Russia
Vyacheslav V. Stupak
Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Russian Federation
DMSc, Prof., neurosurgeon, Head of Neurosurgical department No.1, Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan, Novosibirsk, Russia
Russian Federation
DMSc, Prof., neurosurgeon, Head of Neurosurgical department No.1, Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan, Novosibirsk, Russia
Ivan A. Stepanov
Irkutsk State Medical University
Russian Federation
postgraduate student, Irkutsk State Medical University, Irkutsk, Russia
Russian Federation
postgraduate student, Irkutsk State Medical University, Irkutsk, Russia
Alexandr I. Kichigin
Irkutsk State Medical University
Russian Federation
postgraduate student, Irkutsk State Medical University, Irkutsk, Russia
Russian Federation
postgraduate student, Irkutsk State Medical University, Irkutsk, Russia
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Review
For citations:
Byvaltsev V.A., Stupak V.V., Stepanov I.A., Kichigin A.I. APPLICATION OF THE APPARENT DIFFUSION COEFFICIENT IN PREOPERATIVE ASSESSMENT OF THE PROLIFERATIVE POTENTIAL OF SPINAL TUMORS. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2017;14(3):93-99. https://doi.org/10.14531/ss2017.3.93-99
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