METASTATIC LESION OF THE SPINE DUE TO RENAL CELL CARCINOMA: OUTCOMES AND SURVIVAL AFTER TUMOR RESECTION
https://doi.org/10.14531/ss2017.4.110-116
Abstract
Objective. To evaluate the impact of surgical intervention and targeted therapy on the results of treatment and survival of patients with metastases of renal cell carcinoma to the spine.
Material and Methods. Retrospective analysis of 100 patients (76 men, 24 women, mean age 58.4 years) with renal cell carcinoma metastases to the spine was carried out. Metastasectomy (en block resection) was performed in 39 patients, palliative decompression and stabilization — in 61. Twenty six patients received adjuvant targeted therapy (7 with metastasectomy, 19 with palliative decompression). The pain syndrome (VAS), neurological status (Frankel scale), and survival time (from the moment of surgery till the lethal outcome or the last follow-up examination) were assessed. The Kaplan – Meier survival analysis and Log-rank test were performed. A p-value < 0.05 was considered significant.
Results. All patients demonstrated restoration of neurologic function and reduction of pain syndrome. There was no significant difference in survival time in patients with metastasectomy and palliative decompression (p = 0.47). Statistically significant survival benefit was observed in patients who underwent targeted therapy (p = 0.0019).
Conclusion. Targeted therapy increases survival time in patients with renal cell carcinoma metastases to the spine. Metastasectomy is advisable with additional targeted therapy.
About the Authors
Nikita S. Zaborowsky
Vreden Russian Research Institute of Traumatology and Orthopаedics
Russian Federation
Russian Federation
MD fellow, Department of Neuroorthopaedics and Bone Oncology, Vreden Russian Research Institute of Traumatology and Orthopаedics
Akademika Baikova str., 8, St. Petersburg, 195427, Russia
Stanislav V. Kostritckii
Moscow Oncology Hospital No. 62
Russian Federation
oncologist at Oncourology Department, Moscow Oncology Hospital No. 62
Russian Federation
oncologist at Oncourology Department, Moscow Oncology Hospital No. 62
Dmitry A. Ptashnikov
Vreden Russian Research Institute of Traumatology and Orthopаedics;
Mechnikov North-West State Medical University
Russian Federation
DMSc, Prof., head of the Department of Neuroorthopaedics and Bone Oncology, Vreden Russian Research Institute of Traumatology and Orthopаedics, St. Petersburg; Mechnikov North-West State Medical University
Russian Federation
DMSc, Prof., head of the Department of Neuroorthopaedics and Bone Oncology, Vreden Russian Research Institute of Traumatology and Orthopаedics, St. Petersburg; Mechnikov North-West State Medical University
Valeriy I. Shirokorad
Moscow Oncology Hospital No. 62
Russian Federation
DMSc, head of Oncourology Department, Moscow Oncology Hospital No. 62
Russian Federation
DMSc, head of Oncourology Department, Moscow Oncology Hospital No. 62
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Review
For citations:
Zaborowsky N.S., Kostritckii S.V., Ptashnikov D.A., Shirokorad V.I. METASTATIC LESION OF THE SPINE DUE TO RENAL CELL CARCINOMA: OUTCOMES AND SURVIVAL AFTER TUMOR RESECTION. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2017;14(4):110-116. https://doi.org/10.14531/ss2017.4.110-116
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