PREDICTING THE NATURAL HISTORY OF CONGENITAL SPINAL DEFORMITY IN CHILDREN
https://doi.org/10.14531/ss2013.4.23-29
Abstract
Objective. To identify prognostic criteria of congenital spinal deformity progression in children on the basis of clinical and anamnestic data, X-ray, biochemical and molecular genetic studies.
Material and Methods. The study included 154 patients (91 girls, 63 boys) aged 6 months to 18 years with congenital spinal deformities associated with improper vertebra formation, fusion or segmentation, and combined anomalies of the spine. They underwent clinical examination with assessment of orthopedic and neurologic status, X-ray examination of the spine, and their anamneses and family histories were investigated. Special attention paid to identify the signs of connective tissue dysplasia of various organs and systems.
Results. Multivariate analysis applying the method of statusmetry showed that high levels of osteocalcin and vitamin D, and TT genotype of -1997G/T polymorphism in the COL1A1gene are more common in children with a stable course of congenital spinal deformity, then in children with progressive deformity, who have higher level of P1NP (amino-terminal propeptide of type I procollagen) and more systems involved in the dysplastic process.
Conclusion. Predictive model for progression of congenital spinal deformity was developed, and a group of children at risk of spinal curvature progression associated with vertebral anomalies was identified.
About the Authors
Irina Vadimovna Kazaryan
Research Pediatric Orthopedic Institute n.a. G.I. Turner, St. Petersburg
Russian Federation
Russian Federation
Sergey Valentinovich Vissarionov
Research Pediatric Orthopedic Institute n.a. G.I. Turner, St. Petersburg
Russian Federation
Russian Federation
Tatyana Sergeyevna Razorenova
Military Medical Museum of the Military Medical Academy n.a. S.M. Kirov, St. Petersburg
Russian Federation
Russian Federation
Valentina Ilyinichna Larionova
Research Pediatric Orthopedic Institute n.a. G.I. Turner, St. Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Kazaryan I.V., Vissarionov S.V., Razorenova T.S., Larionova V.I. PREDICTING THE NATURAL HISTORY OF CONGENITAL SPINAL DEFORMITY IN CHILDREN. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2013;(4):023-029. (In Russ.) https://doi.org/10.14531/ss2013.4.23-29
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