CHONDROBLAST CULTURE AS A POTENTIAL SOURCE FOR TISSUE ENGINEERING IN SPINE INJURY AND DISEASE
Abstract
Morphological and ultrastructural investigations have shown that cultivated cells from the embryonic spine at the stage of chondrogenic differentiation preserve their phenotype during cultivation. The chondroblasts at various differentiation stages (junior, young, and mature) ensure both reparative regeneration and homeostasis of an injured cartilage matrix at the expense of the synthesis of proteoglycans and collagen. The data obtained are the basis for use of primary chondroblast culture in cell engineering for treatment of spine injuries and diseases.
About the Authors
Alla Mikhailovna Zaidman
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Andrey Valentinovich Sakharov
Novosibirsk State Pedagogical University
Russian Federation
Russian Federation
Tamara Dmitryevna Kolokoltsova
State Research Center of Virology and Biotechnology VECTOR, Novosibirsk
Russian Federation
Russian Federation
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Review
For citations:
Zaidman A.M., Sakharov A.V., Kolokoltsova T.D. CHONDROBLAST CULTURE AS A POTENTIAL SOURCE FOR TISSUE ENGINEERING IN SPINE INJURY AND DISEASE. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2004;(4):115-121. (In Russ.)
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