STRUCTURAL AND FUNCTIONAL FEATURES OF HUMAN VERTEBRAL BODY GROWTH PLATE IN IDIOPATHIC SCOLIOSIS
Abstract
Vertebral body growth plates of concave and convex sides of a curve in III-IV degree idiopathic scoliosis were studied by methods of morphology, biochemistry, and ultrastructural analysis. The concave side of vertebral body growth plates has shown zonality impairment, decrease in chondroblasts synthetic potentials, and alteration of cells ultrastructural organization. The synthesis conversion to keratansulphate is observed. The appearance of chondroblasts in cytoplasm and of keratansulphate-related fraction of proteoglycans in matrix combined with chondroitinsulphate number decrease is regarded as reflection of genetic disorders in homeostasis regulation in "cell-matrix" system. The growth asymmetry related to the expression of mutant gene, which regulates the morphogenesis of lateral zones of vertebral body growth plates is a pathogenetic mechanism of deformation development. The hypothesis of secondary compensatory growth zone is presented.
About the Authors
Alla Mikhailovna Zaidman
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Anastasia Viktorovna Korel
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Andrey Valentinovich Sakharov
Novosibirsk State Pedagogical University
Russian Federation
Russian Federation
Valentina Ivanovna Rykova
Institute of Cytology and Genetics, SB RAS
Russian Federation
Russian Federation
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Review
For citations:
Zaidman A.M., Korel A.V., Sakharov A.V., Rykova V.I. STRUCTURAL AND FUNCTIONAL FEATURES OF HUMAN VERTEBRAL BODY GROWTH PLATE IN IDIOPATHIC SCOLIOSIS. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2004;(2):64-73. (In Russ.)
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