SCHEUERMANN’S DISEASE MORPHOGENESIS
https://doi.org/10.14531/ss2005.2.73-83
Abstract
Objective. To specify a morphogenetic pathogenesis of the Scheuermann’s disease.
Material and Methods. Growth plates, intervertebral discs, vertebral body tissue (surgical material) from 25 patients of 12–14 years old with Scheuermann’s disease of Grade II–III were examined. In-depth morphohystochemical, biochemical, and ultrastructural analyses were used to study glycosaminoglycans, oxidation-reduction enzymes, alkaline and acid phosphatase, RNA, DNA, and qualitative and quantitative composition of glycosaminoglycans.
Results. Pathogenetic mechanisms of Scheuermann’s disease development are presented basing of previously obtained data on genetic dependence of this pathology. The starter of the spine kyphotic deformity is a disturbance of proteoglycan molecule synthesis and conformation in ventral growth plates of vertebral bodies. The structural change in proteoglycans, which perform barrier-trophic, informational, and antiinvasive functions results in a decreased mitotic and proliferative activity of chondroblasts. The spine kyphotic deformity develops in association with an active osteogenesis.
About the Authors
Alla Mikhailovna Zaidman
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Anastasia Viktorovna Korel
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Andrey Valentinovich Sakharov
Novosibirsl State Pedagogical University
Russian Federation
Russian Federation
Tatyana Vasilyevna Rusova
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Valentina Ivanovna Rykova
Institute of Citology and Genetics, SB RAS
Russian Federation
Russian Federation
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Review
For citations:
Zaidman A.M., Korel A.V., Sakharov A.V., Rusova T.V., Rykova V.I. SCHEUERMANN’S DISEASE MORPHOGENESIS. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2005;(2):073-083. (In Russ.) https://doi.org/10.14531/ss2005.2.73-83
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