GLYCOSAMINOGLYCANS OF INTERVERTEBRAL DISC TISSUES IN PATIENTS WITH IDIOPATHIC SCOLIOSIS
https://doi.org/10.14531/ss2006.3.84-87
Abstract
Objective. To analyze quantitative and qualitative composition of glycosaminoglycans in intervertebral disc tissues in patients with idiopathic scoliosis.
Material and Methods. Intervertebral discs and growth plates were obtained from 50 patients at the age of 12 to 14 years undergoing surgical correction for idiopathic scoliosis of Grade III–IV with apex in the thoracic spine. Autopsy material (20 samples) from forensic medical examination was used as a norm. Nucleus pulposus, annulus fibrosus and growth plate were anatomically separated from tissues.
Results. It was established that qualitative composition of glycosaminoglycans is changed both in all parts of the intervertebral discs and in growth plate. Abundance of keratan sulfate increased and of chondroitin sulfate decreased. A great deal of nonacetylated hexosamines appeared and abundance of sulfate groups reduced.
Conclusion. Revealed changes are related to the disorders in synthesis and processes of chain modification in glycosaminoglycans.
About the Authors
Tatyana Vasilyevna Rusova
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Olga Nikolayevna Kuleshova
Novosibirsk Branch of the S.N. Fyodorov Eye Microsurgery Complex
Russian Federation
Russian Federation
Dmitry Viktorovich Zhukov
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
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Review
For citations:
Rusova T.V., Kuleshova O.N., Zhukov D.V. GLYCOSAMINOGLYCANS OF INTERVERTEBRAL DISC TISSUES IN PATIENTS WITH IDIOPATHIC SCOLIOSIS. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2006;(3):084-087. (In Russ.) https://doi.org/10.14531/ss2006.3.84-87
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