IMPACT OF TECHNOGENIC FACTORS ON OSTEOPOROSIS ONSET AND PROGRESSION: EXPERIMENTAL MODELING

Abstract

Objective. To study pathogenetic changes in bone tissue under a chronic impact of technogenic environmental factors in the experiment.

Material and Methods. Study was performed in 2-monthaged OXYS and Wistar male rats. Osteotropic effect was taken by water solution of natrium dibutilditiophosphoratum administered intragastrically during four months. Bone tissue specimens from rats of both lines were studied by means of osteodensitometry, morphology, and biochemistry in the course of experiment.

Results. In chronic administration of natrium dibutilditiophosphoratum in maximum allowable dozes the bone tissue of OXYS rats was characterized by alteration in remodeling process without coupling of bone absorption and new bone formation, resulting in inhomogeneous and mosaic structure observed in histological study. Histomorphometry proved disintegration of bone remodeling processes due to the inadequate bone building. These changes predominantly occur in trabecular bone, though they are also observed in the cortical tissue, and in some cases even more evidently.

Conclusion. Long-term exposure to technogenic substance can cause disturbance in bone tissue remodeling. Genetic disposition to osteoporosis could be enhanced by a negative effect of technogenic environmental factors, which change bone balance disturbed by decline in osteoplastic functions, and cause indirectly an activation of bone resorption.