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"Хирургия позвоночника"

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Идиопатический сколиоз как мультифакторное заболевание: систематизированный обзор современной литературы

https://doi.org/10.14531/ss2022.2.19-32

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Аннотация

Цель исследования. Анализ современной литературы по вопросам этиологии и развития идиопатического сколиоза.
Материал и методы. В анализ включены исследования, посвященные этиологическим факторам идиопатического сколиоза. Поиск осуществлен по базам eLibrary, PubMed, Google Scholar. В обзор включены исследовательские и экспериментальные работы, а также систематические обзоры и метаанализы. Критерий исключения – теоретические работы без практического исследования/эксперимента для подтверждения теории. Глубина анализа – 30 лет.
Результаты. Из 456 работ по теме исследования отобраны 153, отвечающие критериям включения/исключения. Выделены основные теории возникновения идиопатического сколиоза: генетическая, нейрогенная, теория дефекта костной и мышечной тканей,
биомеханическая, гормональная, биохимическая, эволюционная, теория влияния окружающей среды и образа жизни.
Заключение. Термин «идиопатический сколиоз» объединяет ряд заболеваний с различными этиопатогенетическими механизмами развития. Идиопатический сколиоз имеет полигенное наследование. За его возникновение в разных популяциях ответственны различные гены, а механизмы прогрессирования запускаются разными эпигенетическими факторами. Дефекты костной и мышечной тканей, патология центральной нервной системы, нарушение биомеханики, гормональные и биохимические отклонения в некоторых случаях могут иметь значимую роль.

Об авторах

А. П. Горбач
Национальный медицинский исследовательский центр травматологии и ортопедии им. акад. Г.А. Илизарова Россия, 640014, Курган, ул. М. Ульяновой, 6
Россия

аспирант



О. М. Сергеенко
Национальный медицинский исследовательский центр травматологии и ортопедии им. акад. Г.А. Илизарова Россия, 640014, Курган, ул. М. Ульяновой, 6
Россия

канд. мед. наук, врач-травматолог-ортопед, врач-нейрохирург, заведующая лабораторией клиники патологии позвоночника и редких заболеваний



Е. Н. Щурова
Национальный медицинский исследовательский центр травматологии и ортопедии им. акад. Г.А. Илизарова Россия, 640014, Курган, ул. М. Ульяновой, 6
Россия

д-р биол. наук, ведущий научный сотрудник научной лаборатории клиники патологии позвоночника и редких заболеваний



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Для цитирования:


Горбач А.П., Сергеенко О.М., Щурова Е.Н. Идиопатический сколиоз как мультифакторное заболевание: систематизированный обзор современной литературы. "Хирургия позвоночника". 2022;19(2):19-32. https://doi.org/10.14531/ss2022.2.19-32

For citation:


Gorbach A.P., Sergeenko O.M., Shchurova E.N. Idiopathic scoliosis as a multifactorial disease: systematic review of current literature. Hirurgiâ pozvonočnika (Spine Surgery). 2022;19(2):19-32. https://doi.org/10.14531/ss2022.2.19-32

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