ГЕНЕТИЧЕСКИЕ МАРКЕРЫ ИДИОПАТИЧЕСКОГО И ВРОЖДЕННОГО СКОЛИОЗОВ И ДИАГНОЗ ПРЕДРАСПОЛОЖЕННОСТИ К ЗАБОЛЕВАНИЮ: ОБЗОР ЛИТЕРАТУРЫ


https://doi.org/10.14531/ss2015.1.27-35

Полный текст:


Аннотация

Представлен обзор литературы по наследованию сколиоза. Данная тема изучается в течение многих десятилетий, обнаружено, что наследование, как правило, сложное, хотя в литературе описаны семьи с четким менделевским принципом передачи сколиоза в поколениях. Естественно, было необходимым попытаться найти генетическую основу заболевания, то есть гены, мутации в которых могут вызывать развитие сколиоза. И такие мутации могут служить в качестве маркеров заболевания, по которым он может быть диагностирован до начала деформации позвоночника. В случаях наследственно детерминированных нарушений позвоночника деформации часто продолжают развиваться даже после операции. Во всех случаях важно знать, какие причины привели к развитию сколиоза. Такая информация важна в оценке риска развития заболевания у пациента, потому что становится возможным предсказать последствия той или иной мутации, а также стратегию и тактику лечения.

Об авторах

Сергей Борисович Кузнецов
Новосибирский НИИ травматологии и ортопедии им. Я.Л. Цивьяна
Россия


Михаил Витальевич Михайловский
Новосибирский НИИ травматологии и ортопедии им. Я.Л. Цивьяна
Россия


Михаил Анатольевич Садовой
Новосибирский НИИ травматологии и ортопедии им. Я.Л. Цивьяна
Россия


Анастасия Викторовна Корель
Новосибирский НИИ травматологии и ортопедии им. Я.Л. Цивьяна
Россия


Екатерина Владимировна Мамонова
Инновационный медико-технологический центр, Новосибирск
Россия


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Дополнительные файлы

Для цитирования: Кузнецов С.Б., Михайловский М.В., Садовой М.А., Корель А.В., Мамонова Е.В. ГЕНЕТИЧЕСКИЕ МАРКЕРЫ ИДИОПАТИЧЕСКОГО И ВРОЖДЕННОГО СКОЛИОЗОВ И ДИАГНОЗ ПРЕДРАСПОЛОЖЕННОСТИ К ЗАБОЛЕВАНИЮ: ОБЗОР ЛИТЕРАТУРЫ. "Хирургия позвоночника". 2015;12(1):27-35. https://doi.org/10.14531/ss2015.1.27-35

For citation: Kuznetsov S.B., Mikhaylovsky M.V., Sadovoy M.A., Korel A.V., Mamonova E.V. GENETIC MARKERS OF IDIOPATHIC AND CONGENITAL SCOLIOSIS, AND DIAGNOSIS OF SUSCEPTIBILITY TO THE DISEASE: REVIEW OF THE LITERATURE. Hirurgiâ pozvonočnika (Spine Surgery). 2015;12(1):27-35. (In Russ.) https://doi.org/10.14531/ss2015.1.27-35

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ISSN 1810-8997 (Print)
ISSN 2313-1497 (Online)