OSSEOINTEGRATION OF COMPOSITE BONE-CERAMIC IMPLANTS N EXPERIMENTAL STUDY
https://doi.org/10.14531/ss2014.4.80-87
Abstract
Objective. To analyze osteoconductive activity of a new composite bone-ceramic material.
Material and Methods. The experiment was conducted on male Wistar rats (5-6 months old, body weight ranged 260-320 g). Cylindrical ceramic alumina-zirconia or composite bone-ceramic implants were introduced into perforatied defects of the compact bone. Osseointegration of experimental specimens was studied on the 15th and 30th days after implantation using light, electron, and fluorescence microscopy.
Results. Simultaneous processes of bone resorption and osteogenesis were observed at all time periods after implantation of ceramic alumina-zirconia specimens in the bone bed. The resorption zone around the implant reached 200-250 microns in width and 400-450 microns in length, and marginal regeneration zone - 100-200 microns and 350-400 microns, respectively. Bone-ceramic composite implantation was characterized by the domination of osteogenesis. A large amount of newly formed bone tissue rich in blood vessels and cellular elements was observed along the whole periphery of the bone-ceramic implant already on the 15th day when it reached 50 to 150 microns in width, and on the 30th day it was 150 to 350 microns.
Conclusion. Implantation of the bone-ceramic composite material in the bone bed leads to the formation of bone tissue at the bone-implant interface in the form of bone bridges having a tendency to immuring the implant in the newly formed bone tissue. This suggests the superior osteoconductive properties of this material.
About the Authors
Irina Anatolyevna Kirilova
Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Russian Federation
Russian Federation
Oleg Svyatoslavovich Taranov
State Research Center of Virology and Biotechnology VECTOR, Novosibirsk
Russian Federation
Russian Federation
Valentina Timofeyevna Podorozhnaya
Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Russian Federation
Russian Federation
References
1. Буякова С.П., Жуков И.А., Козлова А.В. и др. Структура и свойства пористой керамики ZRO2-AL2O3 // Известия высших учебных заведений. Физика. 2011. Т. 54. № 9 (2). С. 120-123. [Buyakova SP, Zhukov IA, Kozlova AV, et al. Structure and properties of porous ZRO2-AL2O3 ceramics. Izvestiya vysshih uchebnyh zavedeniy. Fizika. 2011; 54(9/2): 120-123. In Russian].
2. Заявка на изобретение РФ № 2013138335 от 19.08.2013 г. Композиционный костно-керамический имплантат на основе керамического материала системы оксид циркония-оксид алюминия / Садовой М.А., Кирилова И.А., Подорожная В.Т. и др. [Sadovoy MA, Kirilova IA, Podorozhnaya VT, et al. Composite bone-ceramic implant based on ceramic zirconia-alumina material. Zayavka na izobretenie № 2013138335 ot 19.08.2013. Rossiyskaya Federatsiya. Application for RU Patent No. 2013138335, filing date 19.08.2013. In Russian].
3. Калатур Е.С., Буякова С.П., Кульков С.Н. Деформационное поведение пористых керамик, получаемых из высокодисперсных порошков // Фундаментальные проблемы современного материаловедения. 2011. Т. 8. № 4. С. 95-98. [Kalatur ES, Buyakova SP, Kulkov SN. Deformation behavior of porous ceramics obtained from highly dispersed powders. Fundamental’nye problemy sovremennogo materialovedeniya. 2011; 8(4): 95-98. In Russian].
4. Кирилова И.А., Садовой М.А., Подорожная В.Т. и др. Керамические и костно-керамические имплантаты: перспективные направления (обзор литературы) // Хирургия позвоночника. 2013. № 4. С. 52-62. [Kirilova IA, Sadovoy MA, Podorozhnaya VT, et al. Ceramic and osteoceramic implants: upcoming trends. Hir Pozvonoc. 2013; (4): 52-62. In Russian]. doi: http://dx.doi.org/10.14531/ss2013.4.52-62.
5. Кирилова И.А., Садовой М.А., Подорожная В.Т. и др. Изучение структурных характеристик перспективного для хирургической вертебрологии композиционного костно-керамического материала // Хирургия позвоночника. 2014. № 1. С. 100-110. [Kirilova IA, Sadovoy MA, Podorozhnaya VT, et al. Structural properties of the bone-ceramic composite as a promising material in spinal surgery. Hir. Pozvonoc. 2014; (1): 100-110. In Russian].
6. Кирилова И.А., Подорожная В.Т., Шаркеев Ю.П. и др. Аллогенный композиционный костно-пластический материал «Депротекс»: структура и свойства // Известия вузов. Физика. 2013. № 12/3. С. 75-79. [Kirilova IA, Podorozhnaya VT, Sharkeev YuP, et al. Allogenic composite bone-plastic material Deproteks: structure and properties. Izvestiya Vuzov: Fizika. 2013; (12/3): 75-79. In Russian].
7. Кульков С.Н., Буякова С.П. Фазовый состав и особенности формирования структуры на основе стабилизированного диоксида циркония // Российские нанотехнологии. 2007. Т. 2. № 1-2. С. 119-132. [Kulkov SN, Buyakova SP. Phase composition and peculiarities of structure formation on the basis of stabilized zirconia. Rossiyskie nanotehnologii. 2007; 2(1-2): 119-132. In Russian].
Review
For citations:
Kirilova I.A., Taranov O.S., Podorozhnaya V.T. OSSEOINTEGRATION OF COMPOSITE BONE-CERAMIC IMPLANTS N EXPERIMENTAL STUDY. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2014;(4):80-87. (In Russ.) https://doi.org/10.14531/ss2014.4.80-87
Email this article 