EXPERIMENTAL VALIDATION OF COBLATION AND CHEMICAL DENERVATIONOF INTERVERTEBRAL DISCS IN THE TREATMENT OF DEGENERATIVE SPINE DISEASE
https://doi.org/10.14531/ss2011.4.51-57
Abstract
Objective. To compare histological changes after coblation and denervation of intervertebral disc in a model of degenerative-dystrophic lesion of the spine.
Material and Methods. The experiment included 15 mongrel dogs, in which degenerative changes of the lumbar disc were initiated. Discs were affected by cold plasma and chemical denervation. Animals were sacrificed at 1, 3, and 6 months. Specimens were subjected to histological examination.
Results. In the early period after the alcohol injection a marked cell proliferative response over the entire disc was observed. Coblation caused a similar cell proliferation only in the area of electrode contact, while changes in surrounding tissues were not observed. There were no reliable histological differences between treatment groups in the late period. Coblation causes a destruction of the disc tissue in the area of impact without changes in the long-term period.
Conclusion. Injection of an alcohol solution results in micro-focal diffuse destruction of the disc tissue causing disc fibrosis in the long-term period. The obtained morphological data confirm the mechanism of effective use of alcohol denervation and cold plasma nucleoplasty in the treatment of discogenic pain syndromes caused by the disc protrusion.
About the Authors
Alizhon Nematovich Kudratov
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Aleksey Vladimirovich Evsyukov
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
Aleksandr Vladimirovich Krutko
Novosibirsk Research Institute of Traumatology and Orthopaedics
Russian Federation
Russian Federation
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Review
For citations:
Kudratov A.N., Evsyukov A.V., Krutko A.V. EXPERIMENTAL VALIDATION OF COBLATION AND CHEMICAL DENERVATIONOF INTERVERTEBRAL DISCS IN THE TREATMENT OF DEGENERATIVE SPINE DISEASE. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2011;(4):051-057. (In Russ.) https://doi.org/10.14531/ss2011.4.51-57
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