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Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika)

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TACTICS OF SURGICAL TREATMENT FOR MYELOMA INVOLVEMENT OF THE SPINE AND SPINAL CORD

https://doi.org/10.14531/ss2006.4.55-60

Abstract

Objectives. To analyze the efficacy of contemporary decompressive-and-stabilizing techniques, including percutaneous vertebroplasty, in patients with a spine and spinal cord myelomatosis (SSCM).

Material and Methods. Seventy-two patients with SSCM were evaluated with respect to the results of treatment. Sixty-two patients underwent surgical interventions followed by radiotherapy and chemotherapy: open interventions were performed in 53 (85.5 %) patients and percutaneous vertebroplasty (PVP) – in 9 (14.5 %). Ten patients underwent only a specific therapy for SSCM. Pain regression, neurologic state and quality of life were evaluated after surgery.

Results. Radiotherapy and chemotherapy are the methods of choice for SSCM. However in some cases with increasing neurologic deficit, intractable pains and instability of an involved spine segment a surgical intervention is necessary and capable to prevent catastrophic complications. Best results, regarding neurologic impairments and quality of life, were achieved in a group of patients in whom decompressiveand- stabilizing procedures were performed.

Conclusion. PVP is a minimally invasive procedure ensuring quick regression of a pain syndrome and prevention of pathologic fractures in patients with myelomatosis of the spine.

About the Authors

Revaz Semyonovich Dzhindzhikhadze
S.P. Botkin City Clinical Hospital, Moscow
Russian Federation


Oleg Nikolayevich Dreval
S.P. Botkin City Clinical Hospital, Moscow
Russian Federation


Valery Aleksandrovich Lazarev
S.P. Botkin City Clinical Hospital, Moscow
Russian Federation


Stepan Timofeyevich Vetrile
Central Institute of Traumatology and Orthopaedics n.a. N.N. Priorov, Moscow
Russian Federation


Ivan Nikolayevich Shevelev
N.N. Burdenko Neurosurgical Institute, Moscow
Russian Federation


Elmar Rasimovich Musaev
N.N. Blokhin Cancer Research Center, Moscow
Russian Federation


References

1. Мартынов Ю.С., Орлов В.К., Яриков Д.Е. и др. Поражение спинного мозга при множественной миеломе // Журн. неврологии и психиатрии. 1998. Т. 116. С. 9–13.

2. Bilsky M.H., Shannon F.J., Sheppard S, et al. Diagnosis and management of a metastatic mumors in the atlantoaxial spine // Spine. 2002. Vol. 27. P. 1062–1069.

3. Byrne T.N. Spinal cord compression from epidural metastases // N. Engl. J. Med. 1992. Vol. 327. P. 614–619.

4. Chou D., Gokaslan Z.L. Malignant primary tumors of the vertebral column // In: Berger M.S., Prados M.D. (eds.) Textbook of Neuro-Oncology. Phyladelphia, 2005. P. 517–520.

5. Clarke E. Spinal cord involvement in multiple myelomatosis // Brain. 1956. Vol. 79. P. 332–348.

6. Conklin R., Alexanian R. Clinical classification of plasma cell myeloma // Arch. Intern. Med. 1975. Vol. 135. P. 139–143.

7. Dalton W.S., Bergsagel P.L., Kuehl W.M., et al. Multiple myeloma // Hematology Am. Soc. Hematol. Educ. Program. 2001. P. 157–177.

8. De Gramont A., Benitez O., Brissaud P., et al. Quantification of bone lytic lesions and prognosis in myelomatosis // Scand. J. Haematol. 1985. Vol. 34. P. 78–82.

9. Dickman C.A., Spetzler R.F., Sonntag V.K.H. (eds.). Surgery of the craniovertebral junction. N. Y., 1998.

10. Dickman C.A., Fehlings M.G., Gokaslan Z.L. (eds.). Spinal cord and spinal column tumors: principles and practice. N. Y., 2006.

11. Dimopoulus M.A., Goldstein J., Fuller L., et al. Curability of solitary bone plasmacytoma // J. Clin. Oncol. 1992. Vol. 10. P. 587–590.

12. Dorfman H.D., Czerniak B. (eds.). Bone tumors. St. Louis, 1998.

13. Durr H.R, Wegener B., Krodel A., et al. Multiple myeloma: surgery of the spine: retrospective analysis of 27 patients // Spine. 2002. Vol. 27. P. 320–326.

14. Frankel H.L. Ascending cord lesion in the early stages following spinal injury // Paraplegia. 1969. Vol. 7. P. 111–118.

15. Gertz M.A., Greipp P.R. Multiple myeloma and related plasma cell disorders. Berlin; N. Y., 2004.

16. Gilbert R.W., Kim J.H., Posner J.B. Epidural compression from metastatic tumour: diagnosis and treatment // Ann. Neurol. 1978. Vol. 3. P. 40–51.

17. Henson R.A., Urich H. Cancer and the nervous system: the neurological manifestations of systemic malignant disease. Oxford, 1982.

18. Kapadia S.B. Multiple myeloma: a clinicopathological study of 62 consecutively autopsied cases // Medicine (Baltimore). 1980. Vol. 59. P. 380–392.

19. Karnofsky D.A., Abelmann W.H., Craver L.F., et al. The use of nitrogen mustard in the palliative treatment of carcinoma. With particular reference to bronchogenic carcinoma // Cancer. 1948. Vol. 1. P. 634–656.

20. Kastrinakis N.G., Gorgoulis V.G., Foukas P.G., et al. Molecular aspects of multiple myeloma // Ann. Oncol. 2000. Vol. 11. P. 1217–1228.

21. Knowling M.A., Harwood A.R., Bergsagel D.E. Comparison of extramedullary plasmacytomas with solitary and multiple plasma cell tumors of bone // J. Clin. Oncol. 1983. Vol. 1. P. 255–262.

22. Kyle R.A. Multiple myeloma: review of 869 cases // Mayo Clin. Proc. 1975. Vol. 50. P. 29–40.

23. Longo D.L. Plasma cell disorders // In: Harrison’s Principles of Internal medicine 12th ed. Wilson J.D., Braunwald E., Isselbacher K.J., (eds). N. Y., 1991. P. 1412–1416.

24. Malpas J.S., Bergsagel D.E., Kyle R.A., et al. Myeloma: Biology and management. Saunders, 2004.

25. Mathias J.M., Deramond H., Belkoff S.M. (eds.). Percutaneous vertebroplasty. Springer, 2006.

26. Parkin D.M., Whelan S.L., Ferlay J., et al. Cancer incidence in five continents. Vol. VIII. IARC Scientific Publications No. 155. Lyon, 2002.

27. Ries L.A.G., Eisner M.P., Kosary C.L., et al. SEER Cancer Statistics Review, 1973–1999 // Web site: http://seer.cancer.gov./csr/1973_1999/. 2002. National Cancer Institute. Bethesda, 2004.

28. Silverstein A., Doniger D.E. Neurologic complications of myelomatosis // Arch. Neurol. 1963. Vol. 9. P. 534–544.

29. Tomita K., Kawahara N., Kobayashi T., et al. Surgical strategy for spinal metastases // Spine. 2001. Vol. 26. P. 298–306.

30. Tsang R.W., Cospodarowicz M.K., Pintilie M., et al. Solitary plasmacytoma treated with radiotherapy: impact of tumour size on outcome // Int. J. Radiat. Oncol. Biol. Phys. 2001. Vol. 50. P. 113–120.

31. Unni K.K. Dahlin’s bone tumors. General aspects and data on 11087 cases. Lippincott-Raven, 1996.

32. Veith R.G., Odom G.L. Extradural spinal metastases and their neurosurgical treatment // J. Neurosurg. 1965. Vol. 23. P. 501–508.

33. Woo E., Yu Y.L., Ng M., et al. Spinal cord compression in multiple myeloma: who gets it? // Aust. N. Z. J. Med. 1986. Vol. 16. P. 671–675.


Review

For citations:


Dzhindzhikhadze R.S., Dreval O.N., Lazarev V.A., Vetrile S.T., Shevelev I.N., Musaev E.R. TACTICS OF SURGICAL TREATMENT FOR MYELOMA INVOLVEMENT OF THE SPINE AND SPINAL CORD. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2006;(4):055-060. (In Russ.) https://doi.org/10.14531/ss2006.4.55-60



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