GIANT CELL TUMORSOF THE SPINE IN CHILDREN
https://doi.org/10.14531/ss2011.2.41-47
Abstract
Objective. To study clinical and radiological signs, and outcomes of treatment of giant cell tumor (GCT) of the spine in children.
Material and Methods. Clinical and radiological features, therapeutic approach, and results of treatment of six children aged from 10 to 15 years with GCT of the spine were analyzed.
Results. All patients underwent radical reconstruction of the spine with singlestep tumor removal. Shortterm surgery outcomes demonstrate reduction of pain, regression of neurological disorders, and restoration of the spine support. Five children have an ordinary lifestyle without subjective complaints. Recurrence of GCT was diagnosed in one case.
Conclusion. Clinical and radiological signs of GCT are not specific in comparison with other monosegmental destructivelytic vertebral lesions. Pain and neurological disorders are typical clinical manifestations of GCT of the spine. СТ and MRI examinations are highly informative methods for determination of the tumor dissemination and aggressiveness, and percutaneous biopsy – for its preoperative verification. Radical GCT removal with spine support restoration is the only justified method for GCT treatment in children.
About the Authors
Aleksandr Yuryevich Mushkin
St.Petersburg Research Institute of Phthisiopulmonology, St.Petersurg
Russian Federation
Russian Federation
Denis Borisovich Malamashin
St.Petersburg Research Institute of Phthisiopulmonology, St.Petersurg
Russian Federation
Russian Federation
References
1. Алиев М.Д., Тепляков В.В., Каллистов В.Е. и др.Современные подходы к хирургическому лечению метастазов злокачественных опухолей в кости // Практ. онкология. 2001. № 1 (5). С. 39–43.
2. Бабкин А.В. Современные возможности диагностики и хирургии опухолей позвоночника // Травматол. и ортопед. России. 2008. № 3. С. 74–76.
3. Банержи А. Медицинская статистика понятным языком: вводный курс. М., 2007.
4. Волков М.В. Болезни костей у детей. М., 1985.
5. Дулаев А.К., Орлов В.П., Надулич К.А. и др. Хирургическое лечение больных с опухолями позвоночника // Актуальные вопросы травматологии и ортопедии. СПб., 2006. С. 111.
6. Маламашин Д.Б. Биопсия в дифференциальной диагностике заболеваний позвоночника с ограниченной деструкцией у детей: Автореф. дис. … канд. мед. наук. М., 2009.
7. Мушкин А.Ю., Ульрих Э.В., Малярова Е.Ю. Укорачивающая вертебротомия при гигантоклеточной опухоли позвоночника у ребенка // Хирургия позвоночника. 2007. № 1. С. 60–63.
8. Некачалов В.В. Патология костей и суставов: Руководство. СПб., 2000.
9. Усиков В.Д., Пташников Д.А. Реконструктивные операции в комплексной терапии больных с гигантоклеточной опухолью позвоночника // Травматол. и ортопед. России. 2005. № 1 (34). С. 12–15.
10. Arkader A., Dormans J.P. Benign primary tumors of spine // In: Surgery of Pediatric Spine / Ed. by: D.H. Kim, R.R. Betz, S.L. Huhn. N. Y., 2008. P. 306–319.
11. Boriani S., Weinstein J.N., Biagini R. Primary bone tumors of spine. Terminology and surgical staging // Spine. 1997. Vol. 22. P. 1036–1044.
12. Campanacci M., Boriani S., Giunti A. Giant cell tumors of the spine // In: Tumors of the Spine: Diagnosis and Clinical Management / Ed. by: N. Sunderasan, H.H. Schmidek, A.L. Schiller, et al. Philadelphia, 1990. P. 163–172.
13. Gelb D.E., Bridwell K.H. Bening tumors of the spine // In: The Textbook of Spinal Surgery / Ed. by: K.H. Bridwell, R.L. DeWald. Philadelphia, 1997. P. 1959–1981.
14. Kawahara N., Tomita K., Tsuchiya H. Total en bloc spondylectomy: a new surgical technique for malignant vertebral tumors // In: Surgical Approach to the Spine / Ed. by: R.G. Watkins. N. Y., 2003. P. 309–325.
15. Meyers S.P. MRI of Bone and Soft Tissue Tumors and Tumorlike Lesions. Differential Diagnosis and Atlas. Stuttgart; N. Y., 2008.
16. Murakami H., Kawahara N., Abdel-Wanis M.E., et al.Total en bloc spondylectomy // Semin. Musculoskelet. Radiol. 2001. Vol. 5. P. 189–194.
17. Springfield D.S. Bone and soft tissue tumors // In: Pediatric Orthopaedics / Ed. by: R.T. Morrissy, S.L. Weinstein. Philadelphia, 1996. P. 423–457.
Review
For citations:
Mushkin A.Yu., Malamashin D.B. GIANT CELL TUMORSOF THE SPINE IN CHILDREN. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2011;(2):041-047. (In Russ.) https://doi.org/10.14531/ss2011.2.41-47
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