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"Хирургия позвоночника"

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Применение различных материалов и лекарственных средств в профилактике развития послеоперационного поясничного эпидурального фиброза: обзор литературы

https://doi.org/10.14531/ss2021.2.83-92

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Аннотация

Статья представляет собой обзор современных литературных данных, посвященных применению различных материалов и лекарственных средств в профилактике развития послеоперационного поясничного эпидурального фиброза. Поиск литературных источников производили в базах данных Pubmed, Medline, EMBASE, Cochrane Library и eLibrary. Формирование и разрастание фиброзной ткани в эпидуральном пространстве с последующей адгезией ткани к твердой мозговой оболочке является ведущей причиной болевой афферентации в поясничном отделе позвоночного столба и/или в нижних конечностях. В патофизиологии формирования соединительной ткани в эпидуральном пространстве важнейшую роль играют некоторые молекулярные и клеточные механизмы. Представлен анализ экспериментальных и клинических исследований, изучающих эффективность различных материалов и лекарственных средств. Изложены современные данные о новых терапевтических подходах к профилактике послеоперационного эпидурального фиброза. Обозначены актуальные, остающиеся нерешенными вопросы, обусловливающие необходимость дальнейших исследований по изучению патофизиологии эпидурального фиброза.

Об авторах

К. Ц. Эрдынеев
Республиканская клиническая больница скорой медицинской помощи им. В.В. Ангапова Россия, 660023, Улан-Удэ, пр. Строителей, 1
Россия

заведующий отделением нейрохирургии



В. А. Сороковиков
Иркутский научный центр хирургии и травматологии Россия, 664003, Иркутск, ул. Борцов Революции, 1
Россия

д-р мед. наук, проф., директор



Д. Н. Самбуев
Республиканская клиническая больница скорой медицинской помощи им. В.В. Ангапова Россия, 660023, Улан-Удэ, пр. Строителей, 1
Россия

канд. мед. наук, главный врач



В. П. Саганов
Бурятский государственный университет им. Д. Банзарова Россия, 670000, Улан-Удэ, ул. Смолина, 24А
Россия

д-р мед. наук, доцент кафедры госпитальной хирургии



П. М. Жербаханов
Республиканская клиническая больница скорой медицинской помощи им. В.В. Ангапова Россия, 660023, Улан-Удэ, пр. Строителей, 1
Россия

врач-нейрохирург отделения нейрохирургии



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Для цитирования:


Эрдынеев К.Ц., Сороковиков В.А., Самбуев Д.Н., Саганов В.П., Жербаханов П.М. Применение различных материалов и лекарственных средств в профилактике развития послеоперационного поясничного эпидурального фиброза: обзор литературы. "Хирургия позвоночника". 2021;18(2):83-92. https://doi.org/10.14531/ss2021.2.83-92

For citation:


Erdyneev K.T., Sorokovikov V.A., Sambuev D.N., Saganov V.P., Zherbakhanov P.M. The use of various materials and drugs for the prevention of the development of postoperative lumbar epidural fibrosis: literature review. Hirurgiâ pozvonočnika (Spine Surgery). 2021;18(2):83-92. (In Russ.) https://doi.org/10.14531/ss2021.2.83-92

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