Preview

Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika)

Advanced search

MORPHOFUNCTIONAL LAWS REGULATING CHONDROGENESIS IN VERTEBRAL AND ILIAC BONE GROWTH PLATES

https://doi.org/10.14531/ss2013.3.68-80

Abstract

Objective. To perform comparative analysis of the laws of formation and genetic regulation of chondrogenesis in healthy vertebral growth plates and iliac bone growth plates.

Material and Methods. Growth plates of vertebral bodies and iliac articular cartilage obtained from 10 mini-pigs in the period of intensive growth were investigated. The following studies were performed: morphohistochemistry, electron microscopy, immunohisochemistry, gene expression study, biochemical study of proteoglycans and GAGs, and morphometric analysis.

Results. Structural and functional organization of cells and matrix, and periodization of the processes of proliferation, differentiation, and genetic regulation (expression of aggrecan, lumican, Pax1, Sox9, HAPLN1, etc.) were similar in the examined growth plate specimens.

Conclusion. The processes of genetic regulation of chondrogenic differentiation of chondroblasts in the growth plates of vertebral bodies and the iliac bone crest are synchronous.

About the Authors

Alla Mikhailovna Zaidman
Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Russian Federation


Mikhail Anatolyevich Sadovoy
Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Russian Federation


Elena Leonidovna Strokova
Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Russian Federation


Anastasia Viktorovna Korel
Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Russian Federation


Tatyana Vasilyevna Rusova
Novosibirsk Research Institute of Traumatology and Orthopaedics n.a. Ya.L. Tsivyan
Russian Federation


References

1. Васюра А.С., Новиков В.В., Михайловский М.В. и др. Хирургическое лечение сколиоза с применением метода транспедикулярной фиксации // Хирургия позвоночника. 2011. № 2. С. 27–34.

2. Русова Т.В., Рыкова В.И., Корель А.В. и др. Гликозаминогликаны пластинки роста тела позвонков у больных идиопатическим сколиозом // Бюллетень экспериментальной биологии и медицины. 2005. Т. 139, № 6. С. 738–740.

3. Тихонов В.Н. Лабораторные мини-свиньи: генетика и медико-биологическое использование. Новосибирск, 2010.

4. Ali Fazal M, Edgar M. Detection of adolescent idiopathic scoliosis. Acta Orthop Belg. 2006;72:184–186.

5. Campbell RM, Smith MD, Mayes TC, et al. The characteristics of thoracic insufficiency syndrome associated with fused ribs and congenital scoliosis. J Bone Joint Surg Am. 2003;85:399–408.


Review

For citations:


Zaidman A.M., Sadovoy M.A., Strokova E.L., Korel A.V., Rusova T.V. MORPHOFUNCTIONAL LAWS REGULATING CHONDROGENESIS IN VERTEBRAL AND ILIAC BONE GROWTH PLATES. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2013;(3):068-080. (In Russ.) https://doi.org/10.14531/ss2013.3.68-80



Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1810-8997 (Print)
ISSN 2313-1497 (Online)