MORPHOFUNCTIONAL LAWS REGULATING CHONDROGENESIS IN VERTEBRAL AND ILIAC BONE GROWTH PLATES
https://doi.org/10.14531/ss2013.3.68-80
Abstract
Objective. To perform comparative analysis of the laws of formation and genetic regulation of chondrogenesis in healthy vertebral growth plates and iliac bone growth plates.
Material and Methods. Growth plates of vertebral bodies and iliac articular cartilage obtained from 10 mini-pigs in the period of intensive growth were investigated. The following studies were performed: morphohistochemistry, electron microscopy, immunohisochemistry, gene expression study, biochemical study of proteoglycans and GAGs, and morphometric analysis.
Results. Structural and functional organization of cells and matrix, and periodization of the processes of proliferation, differentiation, and genetic regulation (expression of aggrecan, lumican, Pax1, Sox9, HAPLN1, etc.) were similar in the examined growth plate specimens.
Conclusion. The processes of genetic regulation of chondrogenic differentiation of chondroblasts in the growth plates of vertebral bodies and the iliac bone crest are synchronous.
About the Authors
Alla Mikhailovna ZaidmanRussian Federation
Mikhail Anatolyevich Sadovoy
Russian Federation
Elena Leonidovna Strokova
Russian Federation
Anastasia Viktorovna Korel
Russian Federation
Tatyana Vasilyevna Rusova
Russian Federation
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Review
For citations:
Zaidman A.M., Sadovoy M.A., Strokova E.L., Korel A.V., Rusova T.V. MORPHOFUNCTIONAL LAWS REGULATING CHONDROGENESIS IN VERTEBRAL AND ILIAC BONE GROWTH PLATES. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2013;(3):068-080. (In Russ.) https://doi.org/10.14531/ss2013.3.68-80