EXPERIMENTAL SUBSTANTIATION OF 18.75 MG/KG DIMEPHOSPHON USE FOR IN SPINAL CORD INJURY
https://doi.org/10.14531/ss2007.1.69-74
Abstract
Objective. To substantiation an appropriate concentration of dimephosphon for evaluation of its effect on function of the injured spinal cord.
Material and Methods. The experiment was carried out in 40 mongrel dogs divided in three groups. Spinal pathway conductivity was studied by transcranial magnetic stimulation of the brain motor cortex, and a state of the lumbosacral motoneurons – by stimulation electromyography before and after spinal cord injury. Injured spinal cord specimens were histologically examined. In the third group of animals dimephosphon in a doze of 18.75 mg/kg was injected intravenously during 10 days after spinal cord injury.
Results. In 90 % of animals of the third group transcranial stimulation produced motor responses in the anterior tibial muscles in one day after injury. Latent periods of motor responses did not definetely change, which evidenced for preservation of the spinal cord conduction. Dimephosphon reduced the quantity of reflectory reacting motorneurones in acute period of trauma, which is also confirmed by lesser potentiation of reflectory reaction value at high-frequency tetanization.
Conclusion. Dimephosphon promotes the reparation and restoration of function of the injured spinal cord segments effecting the bloodstream and neuronal activity of the spinal cord.
About the Authors
Rustem Faridovich Tumakaev
Research Center “Restorative Traumatology and Orthopaedics”, Kazan
Russian Federation
Russian Federation
Guzel Guljusovna Yafarova
Research Center “Restorative Traumatology and Orthopaedics”, Kazan
Russian Federation
Russian Federation
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Review
For citations:
Tumakaev R.F., Yafarova G.G. EXPERIMENTAL SUBSTANTIATION OF 18.75 MG/KG DIMEPHOSPHON USE FOR IN SPINAL CORD INJURY. Russian Journal of Spine Surgery (Khirurgiya Pozvonochnika). 2007;(1):069-074. (In Russ.) https://doi.org/10.14531/ss2007.1.69-74
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