SPINE PATHOLOGY AND PHENOTYPIC SIGNS OF CONNECTIVE TISSUE DYSPLASIA IN PRIMARY JUVENILE GLAUCOMA

Abstract

Objective. To reveal the spine pathology and phenotypic markers of nondifferentiated connective tissue dysplasia (DCT) syndrome, and to determine their severity level in patients with a primary juvenile glaucoma and myopia. Material and Мethods. A total of 50 patients at the age of 12 to 32 years (23 male, 27 female) with a primary juvenile glaucoma in 43 cases associated with different grades of myopia were examined. Examination in all cases included ophthalmologic and clinical study with a complex assessment of outer phenotypic markers. Spine pathology was revealed by the method of computer optical topography. Results. Phenotipic signs of connective tissue dysplasia were detected in patients with a primary juvenile glaucoma and myopia. These signs included such spinal pathologies, as flat back, scoliosis, functional instability of the cervical spine, as well as platypodia and skin changes. Grade I of connective tissue dysplasia was observed in 16 % of cases, grade II – in 80 %, and grade III – in 4 %. Conclusion. The presence of connective tissue dysplasia results in the development of myopia and primary juvenile glaucoma, and determines the progression of disease.